Differences in the relationship between pack-years and lung function measures by genetic ancestry and race/ethnicity were tested in full multivariable models using the –2 log likelihood test of nested models with and without the interaction terms on an additive scale for lung function and lung density and a multiplicative scale for airflow obstruction. Sensitivity analyses were performed on the converse scales. As race and PCs of ancestry are collinear, they were not included in the same models; rather, two separate sets of analyses were performed. All models met the assumptions for linear and logistic regression, respectively. Presented results are untransformed. Statistical significance was defined as two-tailed p values <0.05. Analyses were performed using SAS V.9.2 (SAS Institute, Cary, North Carolina, USA).
Show
Among 3344 participants for the spirometry analyses using notice-reported race, 35% had been low-Latina Caucasian, 26% African-American, 22% Latina and step step step one7% Chinese-Western. The backdrop from Latina professionals is 51% North american country, 14% Puerto Rican, 14% Dominican, 4% Cuban and 17% most other record. The brand new mean many years is actually 66 decades; 48% was male subjects. In every, 11% were newest smokers and you may 45% previous cigarette smokers, having an average out of 18 pack-numerous years of tobacco (IQR 6, 36) certainly one of previously-cigarette smokers. „Collective smoking, genetic ancestry and you can lung means certainly one of people“ weiterlesen